Short- versus standard-course intravenous antibiotics for peri-prosthetic joint infections managed with debridement and implant retention: a randomised pilot trial using a desirability of outcome ranking (DOOR) endpoint

Peri-prosthetic joint infection (PJI) is a devastating complication of joint replacement surgery. Determining the optimal duration of intravenous (IV) antibiotics for PJI managed with debridement and implant retention (DAIR) is a research priority.

Citation:
Manning L, Metcalf S, Dymock M, Robinson O, Clark B, Nelson R, …………. et al in collaboration with the Australasian Society for Infectious Diseases Clinical Research N. Short- versus standard-course intravenous antibiotics for peri-prosthetic joint infections managed with debridement and implant retention: a randomised pilot trial using a desirability of outcome ranking (DOOR) endpoint. Int J Antimicrob Agents. 2022.

Keywords:
Arthroplasty; Debridement and implant retention; Desirability of outcome ranking (DOOR) score; Ordinal endpoint; Prosthetic joint infection

Abstract:
Peri-prosthetic joint infection (PJI) is a devastating complication of joint replacement surgery. Determining the optimal duration of intravenous (IV) antibiotics for PJI managed with debridement and implant retention (DAIR) is a research priority.