PrEggNut Study: protocol for a randomised controlled trial investigating the effect of a maternal diet rich in eggs and peanuts from <23 weeks' gestation during pregnancy to 4 months' lactation on infant IgE-mediated egg and peanut allergy outcomes

Clinical studies supported by immunological data indicate early life intervention strategies to be promising in reducing the growing global burden of food allergies. The events that predispose to food allergy, including the induction of allergen-specific immune responses, appear to be initiated early in development.

Citation:
Palmer DJ, Sullivan TR, Campbell DE, ……….. Prescott SL, Grivell R, Makrides M. PrEggNut Study: protocol for a randomised controlled trial investigating the effect of a maternal diet rich in eggs and peanuts from <23 weeks' gestation during pregnancy to 4 months' lactation on infant IgE-mediated egg and peanut allergy outcomes. BMJ Open. 2022;12(6):e056925.

Keywords:
Allergens; Arachis; Diet; Egg Hypersensitivity; Food Hypersensitivity; Immunoglobulin E; Infant; Lactation; Peanut Hypersensitivity/prevention & control; Pregnancy; Randomized Controlled Trials; Immunology; Nutrition & dietetics; Perinatology; Preventive medicine

Abstract:
Clinical studies supported by immunological data indicate early life intervention strategies to be promising in reducing the growing global burden of food allergies. The events that predispose to food allergy, including the induction of allergen-specific immune responses, appear to be initiated early in development.