Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies

Citation:
Troy NM, Strickland D, Serralha M, de Jong E, Jones AC, Read J, Galbraith S, Islam Z, Kaur P, Mincham KT, Holt BJ, Sly PD, Bosco A, Holt PG. Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies. J Allergy Clin Immunol. 2022;150(1):93-103

Keywords:
Gene coexpression networks; immune training; infants; peripheral blood; mononuclear cells; Severe lower respiratory tract infections; transcriptomics

Abstract:
Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear.