Cancer therapies inducing DNA damage

The induction of DNA damage has been employed as an anticancer strategy for more than 100years, first starting with the use of radiation to treat stomach cancer followed by the first uses of DNA-damaging chemotherapy to treat childhood leukemia.

Citation:
Buck J, Bowden N, Endersby R. Cancer therapies inducing DNA damage. Epigenetics and DNA Damage: Elsevier; 2022;33: Chapter 12:205-25.

Keywords:
Cancer therapy; Cytotoxic chemotherapy; DNA damage; DNA damage response; Radiotherapy

Abstract:
The induction of DNA damage has been employed as an anticancer strategy for more than 100years, first starting with the use of radiation to treat stomach cancer followed by the first uses of DNA-damaging chemotherapy to treat childhood leukemia.