An eight-plex immunoassay for Group A streptococcus serology and vaccine development

Group A Streptococcus (GAS) is a major human pathogen responsible for superficial infections through to life-threatening invasive disease and the autoimmune sequelae acute rheumatic fever (ARF). Despite a significant global economic and health burden, there is no licensed vaccine available to prevent GAS disease. Several pre-clinical vaccines that target conserved GAS antigens are in development.

Citation:
Whitcombe AL, Han F, McAlister SM, Kirkham LAS, Young PG, Ritchie SR, et al. An eight-plex immunoassay for Group A streptococcus serology and vaccine development. J Immunol Methods. 2022;500.

Keywords:
Antibodies; Dried blood spots; Group A Streptococcus; IgG; Multiplex assay; Vaccine

Abstract:
Group A Streptococcus (GAS) is a major human pathogen responsible for superficial infections through to life-threatening invasive disease and the autoimmune sequelae acute rheumatic fever (ARF). Despite a significant global economic and health burden, there is no licensed vaccine available to prevent GAS disease. Several pre-clinical vaccines that target conserved GAS antigens are in development.