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The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

The bone marrow microenvironment plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression.

Citation:
Anderson D, Skut P, Hughes AM, Ferrari E, Tickner J, Xu J, …… Malinge S, Kees UR, Kotecha RS, Lassmann T, Cheung LC. The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution. Sci Rep. 2020;10(1):19173.

Keywords:
Animals; B-Lymphocytes/metabolism/pathology; Bone marrow/metabolism/pathology; Bone Marrow Cells/metabolism; Disease Progression; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism/pathology; Proto-Oncogene Proteins c-myc/metabolism; Repressor Proteins/metabolism; Tumor Microenvironment

Abstract:
The bone marrow microenvironment plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression.