Systems biology and bile acid signalling in microbiome-host interactions in the cystic fibrosis lung

The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis.

Citation:
Woods DF, Flynn S, Caparrós-Martín JA, Stick SM, Jerry Reen F, O’gara F. Systems biology and bile acid signalling in microbiome-host interactions in the cystic fibrosis lung. Antibiotics. 2021;10(7).

Keywords:
Pseudomonas aeruginosa; aspiration; bile acids; chronic infection; cystic fibrosis; gastro-oesophageal reflux; inflammation; lung; microbiota; pathogen

Abstract:
The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis (CF).