Lung inflammation and simulated airway resistance in infants with cystic fibrosis

Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance.

Citation:
DeBoer EM, Kimbell JS, Pickett K, Hatch JE, ...... Hall GL, King L, Ramanauskas F, Rosenow T, Stick SM, et al. Lung inflammation and simulated airway resistance in infants with cystic fibrosis. Respir Physiol Neurobiol. 2021;293.

Keywords:
Airway mechanics; Computational fluid dynamics; Pediatrics

Abstract:
Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance.