Genetic association study of childhood aggression across raters, instruments, and age

Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap.

Citation:
Ip HF, van der Laan CM, Krapohl EML, Brikell I, ….. Whitehouse AJO, Pennell CE, Klump KL, et al. Genetic association study of childhood aggression across raters, instruments, and age. Transl Psychiatry. 2021;11(1).

Keywords:
Adolescent; Aggression; Child; Genetic Association Studies; Genome-Wide Association Study; Human; Infant; Mental Disorders

Abstract:
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap.