Small nucleolar RNA networks are up-regulated during human anaphylaxis

Anaphylaxis is a severe, potentially life-threatening allergic reaction driven primarily by the activation of mast cells. We still fail to understand factors underlying reaction severity. Furthermore, there is currently no reliable diagnostic test to confirm anaphylaxis in the emergency department.

Citation:
McGrath FM, Francis A, Fatovich DM, Macdonald SPJ, Arendts G, Bosco A, et al. Small nucleolar RNA networks are up-regulated during human anaphylaxis. Clin Exp Allergy. 2021.

Keywords:
Allergy; anaphylaxis; biomarker; differential diagnosis; sepsis; small nucleolar RNA; snoRNA

Abstract:
Anaphylaxis is a severe, potentially life-threatening allergic reaction driven primarily by the activation of mast cells. We still fail to understand factors underlying reaction severity. Furthermore, there is currently no reliable diagnostic test to confirm anaphylaxis in the emergency department.