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Dysregulated Notch Signaling in the Airway Epithelium of Children with Wheeze

The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined.

Citation:
Iosifidis T, Sutanto EN, Montgomery ST, Agudelo-Romero P, Looi K, Ling KM, Shaw NC, Garratt LW, Hillas J, Martinovich KM, Kicic-Starcevich E, Vijayasekaran S, Lannigan FJ, Rigby PJ, Knight, Stick SM, Kicic A. Dysregulated Notch Signaling in the Airway Epithelium of Children with Wheeze. J Pers Med. 2021;11(12).

Keywords:
Airway epithelium; Notch; Pediatrics; Wheeze; Wound repair

Abstract:
The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined.