Sleep-disordered breathing in Australian children with Prader-Willi syndrome following initiation of growth hormone therapy

Citation:
Caudri D, Nixon GM, Nielsen A, Mai L, Hafekost CR, …… Jacoby P, Wilson AC, Downs J, Choong CS. Sleep-disordered breathing in Australian children with Prader-Willi syndrome following initiation of growth hormone therapy. J Paediatr Child Health. 2021.

Keywords:
Prader-Willi syndrome; central sleep apnoea; growth hormone; obstructive sleep apnoea; polysomnography; sleep-disordered breathing

Abstract:
In children with Prader-Willi syndrome (PWS), growth hormone (GH) improves height and body composition; however, may be associated with worsening sleep-disordered breathing (SDB). Some studies have reported less SDB after GH initiation, but follow-up with polysomnography is still advised in most clinical guidelines.