Surfactant protein disorders in childhood interstitial lung disease

Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis. Surfactant proteins, such as surfactant protein B and surfactant protein C, contribute to function and stability of surfactant film.

Citation:
Singh J, Jaffe A, Schultz A, Selvadurai H. Surfactant protein disorders in childhood interstitial lung disease. Eur J Pediatr. 2021.

Keywords:
Abca3; Sftpb; Sftpc; Surfactant; Ttf1; chILD

Abstract:
Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis. Surfactant proteins, such as surfactant protein B and surfactant protein C, contribute to function and stability of surfactant film.