Global molecular diversity of RSV – the “INFORM RSV” study

Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age.

Citation:
Langedijk AC, Lebbink RJ, Naaktgeboren C, Richmond P, Martinon-Torres F, Nunes M, et al. Global molecular diversity of RSV – the “INFORM RSV” study. BMC Infectious Diseases. 2020;20(1):450.

Keywords:
Molecular epidemiology; Monoclonal antibodies; Next generation sequencing; Respiratory syncytial virus; Temporal and geographical diversity; Vaccines

Abstract:
Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age.