Motor abnormalities in Rett Syndrome

For most individuals, there is initial developmental progress followed by regression at around 6–30 months. The classic signs of RTT then become apparent.

Citation:
Downs J, Temudo T. Motor abnormalities in Rett Syndrome. In: Kaufmann WE, Percy A, Clarke A, Leonard H, Naidu S, editors. Rett Syndrome: Mac Keith Press; 2017.

Keywords:
Chapters, Intellectual disability, Neurogenetics, Neurology, Paediatrics, Rett Syndrome

Abstract:
The early descriptions of Rett syndrome (RTT) by Andreas Rett and Bengt Hagberg highlighted altered movement skills which are now recognized as core features of the syndrome. For most individuals, there is initial developmental progress followed by regression at around 6–30 months. The classic signs of RTT then become apparent, including loss of hand and communication skills, the development of stereotypical hand movements, and impairment of gait. Therefore, RTT is essentially a movement disorder.