Authors:
Waithman J, Gebhardt T, Bedoui S.
Authors notes:
European Journal of Immunology. 2016;46(3):543-6.
Keywords:
Antigen presentation/processing, Dendritic cells, T cells, Tumor, immunology
Abstract:
The immune system has the ability to specifically identify and eliminate tumors, but the underlying mechanisms responsible for this phenomenon are not fully understood.
A study published in this issue of the European Journal of Immunology now provides new insights into this important problem.
Joncker et al. [Eur. J. Immunol. 2016. 46: 609-618] show that the timely mobilization of tumor antigen-bearing dendritic cells (DCs) from the periphery to the lymph nodes is critical for effective antitumor T-cell immunity, and that DCs present tumor antigens much more efficiently when encountered in the skin rather than in the subcutaneous tissues.