Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103− and XCR1+CD103+ dendritic cells

This report provides new insight into the functional specialization within the broad network of dendritic cells that are responsible for skin immunosurveillance

Authors:
Wylie B, Seppanen E, Xiao K, Zemek R, Zanker D, Prato S, Foley B, Hart PH,... Waithman J.

Authors notes:
OncoImmunology. 2015;4(8):e1019198.

Keywords:
Cancer, cross-presentation, dendritic cells, melanoma, tumor immunity

Abstract:
The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered.

We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin.

Two migratory populations defined as CD103⁻XCR1⁺ and CD103⁺XCR1⁺ efficiently cross-presented melanoma-derived antigen, with the CD103⁻XCR1⁺ DCs surprisingly dominating this process.

These results are critical for understanding how antitumor CD8⁺ T cell immunity is coordinated to tumor antigens present within the skin.