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Maternal pre-pregnancy body mass index and internalizing and externalizing problems in offspring

Exposure to elevated maternal pre-pregnancy BMI is associated with increased levels of internalizing and externalizing problems throughout childhood and...

Authors:
Van Lieshout RJ, Robinson M, Boyle MH

Authors notes:
Canadian Journal of Psychiatry. 2013;58(3):151-159

Keywords:
Adolescent, Body mass index, Child, Externalizing, Internalizing, Mental disorders, Mother, Pregnancy

Abstract:
To determine if maternal pre-pregnancy body mass index (BMI) is associated with increased levels of internalizing and externalizing symptomatology in offspring throughout childhood and adolescence, and if these links persist after adjusting for the confounders of these associations.

Increased maternal pre-pregnancy BMI was associated with stably elevated levels of externalizing problems, and exhibited a statistically significant interaction with internalizing problems over time, indicating that youth born to mothers with higher maternal pre-pregnancy BMIs had less rapid decreases in internalizing scores as they got older.

Significant positive associations between maternal pre-pregnancy BMI and elevated levels of internalizing problems emerged at age 8 and increased through 17.

These findings persisted despite adjustment for confounders.

Exposure to elevated maternal pre-pregnancy BMI is associated with increased levels of internalizing and externalizing problems throughout childhood and adolescence.

Further work is required to establish if these associations are causal.

If elevated maternal pre-pregnancy BMI is causally linked to psychopathology in offspring, it could provide a potentially realizable target for the prevention of mental health problems in youth.