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Standardised mortality is increased three-fold in a population-based sample of children and adolescents with type 1 diabetes

Fatalities in children and adolescents (1-17 yr) with T1DM were identified from the Western Australia Children's Diabetes Database between 1987-2011.

Authors:
O'Grady MJ, Delaney J, Jones TW, Davis EA

Authors notes:
Pediatric Diabetes. 2013;14(1):13-17

Keywords:
Type 1 diabetes, Diabetic ketoacidosis, Hypoglycaemia, Mortality, Dead-in-bed

Abstract:
There are no type 1 diabetes (T1DM) mortality data on Australian children and limited contemporary data on their international counterparts.

Fatalities in children and adolescents (1-17 yr) with T1DM were identified from the Western Australia Children's Diabetes Database between 1987-2011.

Seventeen thousand four hundred and fifty-three patient-years of diabetes data were analysed and 13 deaths were confirmed (six male).

The overall standardised mortality ratio was 3.1 and was highest in the 10-14 yr age group, at 4.6.

Median age at death was 16.4 yr, and median haemoglobin A1c at death was 10.5%.

Cause of death was attributed to diabetes in 10 (77%) cases.

Two patients were found 'dead-in-bed'.

All diabetes-related deaths in subjects with known T1DM occurred outside the hospital setting.