Histiologic chorioamnionitis is associated with reduced incidence of late-onset sepsis in very preterm infants

Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis...

Authors:

Strunk, T. Doherty D., Jaques A., Simmer, K., Richmond, P., Kohan R., Charles, A. and Burgner D

Authors notes:

Pediatrics. 2012 Jan;129(1):e134-41. Epub 2011 Dec 12.

Keywords:

Histiologic chorioamnionitis, reduced incidence, late-onset sepsis, preterm infants, HCA, preterm labour, preterm delivery, chorioamnionitis, modulate postnatal immunity, LOS, coagulase-negative staphylococci, CoNS

Abstract

Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis and may modulate postnatal immunity. Preterm infants are at greatly increased risk of late-onset sepsis (LOS), particularly with coagulase-negative staphylococci (CoNS), but the impact of HCA on the risk of LOS is unknown.