Ndrg1 in development and maintenance of the myelin sheath

CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability

Authors:
King RH, Chandler D, Lopaticki S, Huang D, Blake J, Muddle JR, Kilpatrick T, Nourallah M, Miyata T, Okuda T, Carter KW, Hunter M, Angelicheva D, Morahan G, Kalaydjieva L

Authors notes:
Neurobiol Dis. 2011 Jun;42(3):368-80. Epub 2011 Feb 12

Keywords:
Ndrg1, development, maintenance, myelin sheath

Abstract:
CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability, caused by mutations in the N-myc downstream regulated gene 1 (NDRG1). NDRG1 is expressed at particularly high levels in the Schwann cell (SC), but its physiological function(s) are unknown