Authors:
Hollams E, Hales B, Bachert C, Huvenne W, Parsons F, de Klerk N, Serralha M, Holt B, Ahlstedt S, Thomas W, Sly P, Holt PG
Authors notes:
European Respiratory Journal 2010;36:509-16
Keywords:
Th2-associated immunity, bacteria in asthma in teenagers, susceptibility to asthma
Abstract:
Bacterial colonisation of the airways is associated with increased risk of childhood asthma. Immunoglobulin (Ig)E against bacterial antigens has been reported in some asthmatics, suggesting a role for bacterial-specific type-2 immunity in disease pathogenesis. We aimed to investigate relationships between bacterial-specific IgE amongst teenagers and asthma susceptibility.