No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice

Previous studies have suggested that in vitro modulation of neutrophil chemokines and inflammatory cytokines by neutrophil elastase (NE) does not translate to t

Authors:
Foong RE, Sly PD, Larcombe AN, Zosky GR

Authors notes:
Respiratory Physiology and Neurobiology 2010;173:164-70

Keywords:
neutrophil elastase, influenza-induced cellular recruitment, cytokine production, airway hyperresponsiveness, mice

Abstract:
Previous studies have suggested that in vitro modulation of neutrophil chemokines and inflammatory cytokines by neutrophil elastase (NE) does not translate to the in vivo setting. We aimed to test the role of NE in the recruitment of neutrophils, cytokine production and lung function responses to respiratory viral infection.