The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized

Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis.

Authors:
Ramasawmy R, Menezes E, Magalhães A, Oliveira J, Castellucci L, Almeida R, Rosa ME, Guimarães LH, Lessa M, Noronha E, Wilson ME, Jamieson SE, Kalil J, Blackwell JM, Carvalho EM, de Jesus AR.

Authors notes:
Infect Genet Evol. 2010 Jul;10(5):607-13. Epub 2010 Apr 27.

Keywords:
-2518bp promoter polymorphism, CCL2/MCP1 influences susceptibility, mucosal, localized cutaneous leishmaniasis, Brazil

Abstract:
Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML.