Authors:
Strunk T, Coombs M, Currie A, Richmond P, Golenbock D, Barak LS, Gallington L, Otto M, Burgner D, Levy 0
Authors notes:
PLoSOne 2010; 5(4):e10111. (Impact factor 4.351)
Keywords:
TLR2 mediates recognition of live Staphylococcus epidermidis and is selectively crucial for clearance of bacteremia
Abstract:
Staphylococcus epidermidis (SE) is a nosocomial pathogen that causes catheter-associated bacteremia in the immunocompromised, including those at the extremes of age, motivating study of host clearance mechanisms. SE-derived soluble components engage TLR2; but additional signaling pathways have also been implicated, and TLR2 can play complex, at times detrimental, roles in host defense against other Staphylococcal spp. The role of TLR2 in responses of primary blood leukocytes to live SE and in clearance of SE bacteremia, the most common clinical manifestation of SE infection, is unknown.