Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth

Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory.

Authors:
Van der Most, R. G., Currie, A. J., Cleaver, A. L., Salmons, J., Nowak, A. K., Mahendran, S., Larma, I., Prosser, A., Robinson, B. W., Smyth, M. J., Scalzo, A. A., Degli-Esposti, M. A., Lake, R. A.

Authors notes:
PLoS ONE (2009) 4 9 e6982

Keywords:
cyclophosphamide chemotherapy sensitizes tumor cells, TRAIL-dependent CD8 T cell-mediated immune attack, suppression of tumor growth,

Abstract:
Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to generate anti-tumor immune responses in the context of chemotherapy.