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National Case-Control Study of Childhood Brain Tumours

The Australian Study of Childhood Brain Tumours was a national case-control study into the risk factors for childhood brain tumours (CBT).

Elizabeth Milne, Carol Bower, Nick de Klerk, Peter Dallas

External collaborators:
Bruce Armstrong, Frank van Bockxmeer, Rodney Scott, John Attia, Lin Fritschi, David Ashley, Lesley Ashton, Judith Thompson, Murray Norris , Richard Cohn, Margaret Miller, Luce dalla Pozza, John Daubenton, Timothy Hassall, Maria Kirby, Stewart Kellie, Ross Pinkerton, Frank Alvaro, Angela Alessandri.

The Australian Study of Childhood Brain Tumours was a national case-control study into the risk factors for childhood brain tumours (CBT). It aimed to investigate genetic, dietary and environmental risk factors for CBT.  The study recruited case and control families between 2006 and 2010; data collection was completed in 2011.  The study involved children aged 0-14 years. Case children and their parents were recruited from the nine paediatric oncology units nationwide.  

Funder: NHMRC Grant #404089.

The following papers were published in 2015:

  • Greenop KR, Miller M, Bailey HD, Scott RJ, Attia J, Bower C, van Bockxmeer FM,  Ashton LJ,  Armstrong BK, Milne E.  Paternal dietary folate, B6 and B12 intake and the risk of childhood brain tumors. Nutrition & Cancer. 2015:67(2) 224-230.
  • Greenop KR, Scott RJ, Attia J, Bower C, de Klerk NH, Norris MD, Haber M, Jamieson SJ, van Bockxmeer FM, Gottardo NG, Ashton LJ, Armstrong BK, Milne E. Folate pathway gene polymorphisms and risk of childhood brain tumors: results from an Australian case-control study.  Cancer Epidemiology, Biomarkers and Prevention.  2015: 24(6); 1–7.
  • Greenop KR, Miller M, Bailey HD, de Klerk NH, Attia J, Kellie SJ, Bower C, Armstrong BK, Milne E. Childhood folate, B6, B12 and food group intake and the risk of childhood brain tumors: results from an Australian case-control study.  Cancer Causes and Control. 2015: 26:871–879. doi:10.1007/s10552-015-0562-z
  • Greenop KR, Hinwood A, Fritschi L, Scott RJ, Attia J, Ashton LJ, Heath J, Armstrong BK, Milne E. Vehicle refuelling, use of domestic wood heaters and the risk of childhood brain tumors: results from an Australian case-control study. Pediatric Blood & Cancer 2015;62:229–234 DOI: 10.1002/pbc.25268.